flow trial semaglutide kidney outcomes nejm 2024 hazard ratio FLOW: Kidney outcome results for GLP-1RA flow trial semaglutide kidney outcomes

This explains why studies have found GLP-1/GIPs to be slightly more effective for weight loss compared to GLP-1s

Conversely, if you have genetic patterns favoring GLP-1 pathway activation, semaglutide often provides excellent weight loss with fewer GI side effects

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Genetic variants in the GLP1R gene and related appetite-signaling pathways may influence how quickly you feel satiated and how your weight loss progresses over time

Combination approaches may succeed where single medications partially fail

Mako, Y.-Y