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Unlike medication effects, which are usually aimed at altering action of one receptor or enzyme to ameliorate psychiatric symptoms [e.g., serotonergic pathway, glutamatergic pathway (108)], the low glutamate diet aims to reduce glutamatergic excitotoxicity while concurrently increasing consumption of nutrients known to be protective against excitotoxicity, with the aim of improving neurotransmission (69, 109)

Key Highlights 6.1.1.1

Higher HbA1c levels have also been correlated with reduced hippocampal volume, suggesting that metabolic dysregulation in diabetes may have direct neuroanatomical consequences contributing to depressive symptoms [103]

10.1177/2040622319825567 72 GeM.SunW.XuT.YangR.ZhangK.LiJ.et al (2025)