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Notably, inhibition of the mitochondrial tricarboxylic acid (TCA) cycle or electron transfer chain (ETC) ameliorated these processes and inhibited ferroptosis

doi: 10.1038/mp.2016.196 25 ChenJJGalluzziL

However, the molecules are often too large to penetrate the deeper layers of the dermis effectively

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Galbo T, Perry RJ, Jurczak MJ, Camporez JP, Alves TC, Kahn M, Guigni BA, Serr J, Zhang D, Bhanot S, Samuel VT, Shulman GI (2013) Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo