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First, in a study of nearly 2k adults taking semaglutide, we observe a startling bodyweight uptick post-termination: Second, per reviews of major studies, some peoples weight loss is 40% muscle masswhich is a terrible outcome: Taken together, these side effects mean that, if you start and then stop, youve not only regained much of the weight, but youve lost muscle

The GLP-1 era does not invalidate those capabilities, but it requires something additional that the traditional pathway rarely develops

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