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Open questions How much do we know about the involvement of ferroptosis in innate and adaptive immune pathways

Its metabolized locally by receptor-bearing pituitary cells, which is part of why systemic toxicity is low

Outcomes appear highly context-dependent, reinforcing the need for controlled experimental design and continued mechanistic research

For instance, the intricate link between PD etiology and mitochondrial dysfunction, frequently modulated by complex genetic factors (124), may impact ferroptosis susceptibility

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