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The insulin secretion and the protein levels of ABCA1 were reduced by cholesterol and increased by EX-4 (Figures 1F,G)

RCT, randomized control trial

The discussed studies were obtained from databases (PubMed, SciFinder), using the keyword Pycnogenol and placebo or double-blind. 2 Randomized, double-blind placebo-controlled human clinical studies with Pycnogenol The RDP human clinical studies conducted with Pycnogenol are summarized in Table 1, including a brief description of the study details and main findings

We defined the presence of the comorbidities using the calculated CCI as defined by at least two ambulatory visits with the corresponding ICD9-CM diagnoses during the one year before the index date