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There were faster granulation tissue formation, re-epithelialization, dermal remodeling, and collagen deposition through extracellular signalregulated kinases (ERK)1/2 signaling pathway as well as its downstream targets, including c-Fos, c-Jun, and egr-1

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Experimental models report healing improvements within 14 to 21 days through increased cellular activity and improved nutrient delivery to injured sites

Immunochemical studies with monoclonal antibody F4/80