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Moreover, DOX/aNLG919-loaded CaCO 3 nanoparticles (DNCaNPs) obtained by combining the ICD inducer DOX and the IDO1 inhibitor alkylated NLG919 can induce ICD in cancer cells and can induce effective anti-tumor immune responses by inhibiting IDO1 to limit the production of immunosuppressive kynurenine thereby leading to increased tumor cytotoxic CD8 + T cell infiltration and immunosuppressive Tregs depletion, and the combination of chemotherapy and immunotherapy with this nanoparticles can effectively inhibit tumor growth (168)

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Western blotting was performed in accordance with standardized procedures, and the following primary antibodies were used to specifically recognize: Nrf2 (1:1000

Study details and population characteristics are summarised in Table 1

The gastric stability of BPC-157 is a distinguishing feature most peptides are rapidly degraded by pepsin and hydrochloric acid in gastric fluid

However, we focused this review on sulforaphane due to its overwhelming use in neuronal disease models and clinical trials