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Older adults Researchers over 60 may see slightly slower weight loss and face a higher risk of sarcopenia (muscle loss) during treatment
That doesn't make compounded GLP-1 medications categorically unsafe
doi: 10.1016/j.regpep.2004.06.020 50 MentleinRGallwitzBSchmidtWE
A rational multi-receptor design is a hypothesis to be tested, not an outcome to be assumed and the balance between glucagon's metabolic upside and its capacity to raise glucose is precisely the kind of question that careful clinical trials exist to resolve
This gap has practical implications
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