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Acute manifestations include hypoxia, frostbite, and psychiatric symptoms

It is also a potent MAO inhibitor and carries an FDA boxed warning for serotonin syndrome when combined with SSRIs and similar drugs, a risk most clearly documented at intravenous and higher doses

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) and has been transmitted to the Congress and the Comptroller General for review

Expression of the clock repressor Period2 (Per2) is inversely correlated with claudin-5 levels, supporting circadian regulation of tight junction dynamics (71)

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