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Furthermore, APAP-protein adducts were detected after APAP treatment in human HepaRG cells that express low CYP2E1 levels ( via O-glucuronidation (50%70%) and O-sulfation (approximately 25%) pathways and forms the corresponding conjugates that can be easily excreted by the kidney

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5 The coexistence of DPN with other diabetes-related complications necessitates a comprehensive approach to patient care, especially for elderly patients

However, factors like stress, poor diet, and aging can deplete glutathione levels, making it harder for your body to detoxify effectively