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This phenomenon is observed in epilepsy patients, who experience neural hyperexcitation and an accelerated depletion of NSCs

Chem.279, 1304413053 (2004)

Because melasma is driven by chronic inflammation, calming these pathways is essential for preventing ongoing melanocyte overstimulation and recurrent discoloration

doi: 10.1186/s12576-021-00812-2

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