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When you rely on oral B12 supplements to improve your B12 levels, you may not get the full benefit of your dosage because the nutrients have to get through your digestive system before they enter your bloodstream

"The Relation of Cytotoxin-Associated Gene-A Seropositivity with Vitamin B12 Deficiency in Helicobacter pylori -Positive Patients"

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This does not mean it would be ineffective for every patient but it does raise questions about expectations

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Certain factors, such as dietary restrictions, digestive issues, or age-related changes, can impact B-12 absorption, making supplementation a beneficial option for many individuals.