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The reaction is more common in oral dosing protocols ranging from 100 to 500 micrograms per day and tends to resolve with dose adjustment
[DOI] [PMC free article] [PubMed] [Google Scholar] 58.Abou-Alfa GK, Meyer T, Cheng A-L, El-Khoueiry AB, Rimassa L, Ryoo B-Y, et al
For peptides, this molecular bumping and shaking can cause the amino acid chain to snap