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2001;138(1 Suppl):S46-54

For almost two decades, between the mid-1970s, when carbamazepine and valproic acid were introduced, and 1993, when felbamate was approved, no new seizure drugs were developed for clinical use

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Thyroidectomy/Surgery: Surgery is often the conventional treatment for pregnant or lactating women, for those with ophthalmopathy (again due to radioactive iodine potentially worsening that condition), for those with large goiters, or for those continuing to have hyperthyroidism after anti-thyroid drug therapy and/or radioactive iodine treatment