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However, these drugs have also been linked to severe side effects, raising concerns for patients who trusted in their safety
Currently, there are no effective treatments to completely cure mitochondrial diseases, and gene therapy remains in the experimental stages
TGR inhibitors do not react covalently with GSH, selenocysteine, or TGR, and inhibition of TGR is reversible To evaluate stability of the TGR inhibitors in the presence of GSH and selenocysteine, compound 2 and a known covalent inhibitor of TGR, TRi-1 20,45 , were incubated with GSH or the N-Boc protected methyl ester of selenocysteine, and the reaction mixtures were analyzed by LCMS (Supplementary Figs
Image: Canva Cysteine, an amino acid required for the synthesis of glutathione, can be found in protein-rich foods such as eggs, fish, lean meats, and whey protein
