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Also, some research suggests that Rosmarinus officinalis leaf extracts and some of their metabolites like indirubin (IND), prototype ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 6-formylindolo[3,2-b] carbazole (FICZ) and pityriazepin (PZ) inhibits the AhR activation (Aryl hydrocarbon receptor) in human keratinocytes

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In addition, SARS-CoV-2 ORF3a promotes NRF2 degradation through the recruitment of Keap1, thus weakening the resistance of cells to oxidative stress and promoting ferroptosis [131]

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