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Side Effects & Safety Nausea 44% in STEP trials, most common side effect, dose-dependent Diarrhea 30% in trials Vomiting 24% in trials Constipation 24% in trials Stomach pain 20% in trials Pancreatitis rare but documented

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Aerobic exercise improves insulin sensitivity via PGC-1 and GLUT4 upregulation [97]

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While 2 years is the maximum duration of clinical trials on Semaglutide GLP-1, the length of treatment may be shorter or longer depending on individual circumstances

Here, the need for GLP-1 agonists arises that are stable for a week