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This lack of expression can be explained in light of previous mutagenesis studies which showed that some residues or sequences encompassed by TM5-L0 (chimera M1), ICL5-TM10-TM11 (chimera M4), TM14-TM15-ICL7 (chimera M7) are important for the correct addressing and folding of MRP1 19,34,46,47

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