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Most randomized trials have been conducted in generally healthy populations, limiting generalizability to patients with specific diseases or conditions

Interactions of G proteins with these receptor domains contribute to the separation of the G protein RHD and AHD, disruption of the P loop and the nucleotide-binding pocket, all of which contribute to the release of GDP, one of the key rate-limiting steps in G protein activation 36

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GLP-1 RAs, including semaglutide and liraglutide, are widely used to treat type 2 diabetes and obesity