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The mechanisms proposed have included effects on growth factor activity, on extracellular matrix remodeling in the follicle environment, and on copper-dependent enzymes relevant to follicle biology

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McCord JM (1993) Human disease, free radicals, and the oxidant/antioxidant balance

In the IMPACT trial, pemvidutide achieved mean weight losses of 4.8% and 5.8% with 1.2 and 1.8 mg doses respectively at 24 weeks, compared to 0.5% with placebo, with weight loss curves showing no evidence of plateauing, suggesting continued benefit with longer treatment [49-51]

The result is the bones becoming weak and at risk of breaking much more easily than normal