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Reconstitution: Mix with sterile water before injection

Thus, trigonelline might be an interesting therapeutic strategy as an NAD + modulator to explore in sarcopenia and possibly other chronic conditions

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The serine/glycine synthesis pathway branches from glycolysis via the glycolytic intermediate 3-phospho-glycerate, which can be converted into serine via three enzymatic reactions catalyzed by PHGDH, PSAT1, and PSPH, followed by the reversible interconversion of serine into glycine by SHMT1/2 (Figure 1)(2)

Notably, none of the interventions improved or compromised erectile function

This was a small pilot study (6 participants) results are preliminary and require confirmation in larger trials