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In non-small cell lung cancer (NSCLC), combining 968 with erlotinib reverses erlotinib resistance and decreases both glycolysis and glutamine metabolism [105]

doi: 10.1007/s00125-013-3145-0 54 HoganAETobinAMAhernTCorriganMAGaoatsweGJacksonRet al

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Why cysteine is the rate-limiting factor: The intracellular concentration of cysteine sits close to the Km value of GCL (0.1 to 0.3 mM), meaning the enzyme is operating near its saturation point under normal conditions