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Potential chiral and Aspartimide impurities such as D-Asp9, D-Ser11, D-Leu14.Iso-Asp was tested and found well controlled, still traces of other stereoisomers may present which cannot be resolved chromatographically however in Semaglutide synthesis, all couplings were carried out in presence HOBt at lower temp fallowed by two stage purification using preparative HPLC, this process is capable to control/remove stereoisomers

These typically maintain temperatures within the safe range for 1248 hours, depending on the product

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Last reviewed: June 19, 2026 Last updated: June 19, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

Thomas C, Pellicciari R, Pruzanski M, et al

Your provider should ask about storage practices during follow-up visits, as degraded medication can mimic treatment inefficacy and lead to unnecessary dose adjustments