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PHAT arises most often in the subcutaneous tissue of the lower extremity, particularly the ankle/foot, although other sites include the perineum, buttock, vulva and arm

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Statin therapy inhibits fatty acid synthase via dynamic protein modifications

Mechanistically, cell division and survival were restored upon the addition of an alternative cysteine source, suggesting that GSH is a key cysteine source that promotes Rickettsia cell division