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Meta-analyses have shown that GLUT1 is frequently overexpressed in various solid tumors and is associated with poor prognosis ( In summary, the upregulation of key glycolytic enzymes such as HK, PFK, and PKM2, as well as LDH and lactate transporters MCT1 and MCT4, along with increased expression of the glucose transporter GLUT1, enhances glycolytic activity in tumors, contributes to an acidic TME, and promotes cancer cell invasion and migration