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Specifically, the administration of FOS and GOS decreases the expression of TLR4, TNF-, IL-1, and MMP9 and increases the expression of occludin and IL-10

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This will often be a problem for GSSG, which is present at low concentrations under physiological conditions, at around 1% of intracellular GSH levels

However, in rare cases, very high doses may lead to mild side effects such as headaches, nausea, diarrhea, or skin reactions like itching and rashes

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