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in comparison to the batch produced without histidine, a maximum HMWP reduction of -50% is observed after 31 days and up to 150 days with the addition of 10mM histidine

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H.LowensteinE.MohammadiM.et al (1993)

While hundreds of animal and in-vitro studies showcase its efficacy in healing diverse tissues and protecting against various insults, these results cannot be directly extrapolated to human physiology and disease states

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Initial darkening may appear subtly, with a gradual increase in pigmentation as melanin production continues