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IGF-1 as a Performance-Enhancing Drug (PED): Doping in Sports IGF-1 has gained a reputation as a popular doping agent in sport, implicated in many of the most high-profile doping cases in recent years including the Bay Area Laboratory Co-operative (BALCO) [86], Major League Baseball (MLB) [87] and Tour de France [88] scandals to name a few

With a half-life of 5 days, it requires 4-5 half-lives for the medication to be largely cleared, though trace amounts may persist slightly longer in some individuals

247,248,249,250 Modifications, such as m5C and , reduce the activity of cytokines and biomarkers in dendritic cells, helping mRNA evade the immune system

Weight loss and body composition changes The primary endpoint data tells a compelling story

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