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In a double-blind placebo-controlled study, approximately 80% of men developed an erection satisfactory for intercourse after using PT-141, whether the cause of ED was physical or psychological, and 68% of men reported an increase in sexual desire

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The peptide accelerates regeneration of intestinal mucosa and submucosa, restores tight junction proteins (claudin-1, occludin, ZO-1) that fail in intestinal permeability syndromes, and increases local blood supply through VEGF-mediated angiogenesis