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Binding of perfluorinated fatty acids to serum proteins

315 Given the critical function of glutamine metabolism, GLS inhibitors have been explored as potential CSC-targeting agents

Although the substrate specificity of other OCT family members is insufficiently characterized, their principal ability to transport organic cations justifies inclusion of SLC22A35 in Figure 2

Secondly, it has been indicated that high doses or long-term NAM reduces the methyl group availability and cellular methylation potential via promoting the methyl sink in the form of 1MNA

Second, lack of durable exposure or poor temporal alignment between dosing and physiology suggests pharmacologic failure

Vaira, L