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Both therapies converge on the same cellular signaling pathways, and their combined effect may be greater than the sum of their parts

As with other receptor agonists in this class, the therapeutic effect builds gradually as the dose is escalated and the body adapts to the medicine

However, like most medications, GLP-1s come with potential side effects

Patients should maintain adequate fluid intake and seek medical advice if symptoms are severe or prolonged

These therapeutic effects occur after the medication has entered systemic circulation , not during the absorption phase, which means that the presence or absence of food in the gastrointestinal tract at the time of injection is irrelevant to the drug's pharmacological activity