What follows is an honest map of where the mechanism is solid, where the evidence stops, and what better-evidenced options are sitting in the same slot
Shinjo-Nagahara, S., Hiratsuka, G., Okada, Y., Kitano, Y
AMA Longevity optimization through strength benchmarks, VO max targets, nutrition principles, brain health, supplements, GLP-1 RAs, wearables, and more #382 AMA #80: Longevity optimization through strength benchmarks, VO max targets, nutrition principles, brain health, supplements, GLP-1 RAs, wearables, and more In this special Ask Me Anything (AMA) episode, Peter answers a wide range of questions spanning the topics that come up most often in conversations about longevity and health optimization
Yet, a randomized, double-blind, placebo-controlled trial in 215 men (35-55 years old) found that daily supplementation with B vitamins (at 3 to 13 times the current RDA, except for folic acid, which was included at a dose equivalent to the RDA), vitamin C (500 mg/day), zinc (10 mg/day), and magnesium (100 mg/day) for 33 days had no effect on measured performance of executive functions, including the Stroop color-word test, the peg-and-ball task, and the Wisconsin card-sorting task (134)
Sardar, S
It was developed by modifying four amino acids in the native GHRH(1-29) sequence to increase resistance to enzymatic breakdown
