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Cleveland Clinic explains that starting out with too large of a calorie deficit can lead to side effects like fatigue, headaches, dehydration, nausea and irritability. If you also cut too much protein from your diet, your body may begin breaking down muscle for fuel, which can further impact strength and metabolism. Sleep plays a role too

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PLoS One 10 , e0125192 (2015)

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1 Introduction According to the latest iteration of the definition, sepsis is a life-threatening organ dysfunction resulting from a dysregulated host response to infection (1)