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Key takeaways Semaglutide, used for type 2 diabetes, can cause fatigue, potentially due to its appetite-suppressing effect and caloric deficit it induces, and the experience of tiredness may vary depending on whether its taken orally or as an injection

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For example, eating different foods and doing more physical activity will be good for you

TCN1 binds to vitamin B12 as cobalamin and transports it into cells

Another reason could be that, as semaglutide suppresses appetite, reduces your hunger and makes you feel fuller, eating larger portions of food might cause nausea, bloating, or discomfort

Whether an over-the-counter laxative is appropriate alongside semaglutide is a decision for the licensed provider managing your therapy