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Absolute contraindications Cardiovascular disease

156 FMRP loss of function causes fragile X syndrome and autistic features, which is the most commonly known single-gene cause of ASD

23 Supplementation of 1 mg daily is recommended for patients with specific risk factors (e.g., bariatric/gastric surgery patients, those with severe malnutrition, chronic alcohol use, chronic hemolytic anemia and conditions with high cell turnover, and use of antimetabolite medications such as methotrexate)

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Measurable weight loss is typically visible by weeks 4-8

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