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Comment: One commenter pointed to the significant methodological changes to individual measures finalized in the Fiscal Year (FY) 2026 Inpatient Prospective Payment System (IPPS) final rule (90 FR 36997 through 37027), such as the use of Medicare Advantage (MA) data, changes in risk adjustment models, removal of COVID-19 vaccination measures, and re-baselining of HAI measures, and urged CMS to delay implementation of Stage 2 for a year after updated data is publicly available and after conducting a comprehensive analysis of the combined effects before finalizing further penalties

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Furthermore, CHAC2 also maintains pluripotency through a CHAC1-independent pathway by regulating the NRF2-GCL axis, thereby sustaining GSH biosynthesis and concurrently suppressing ROS production (Wang et al., 2017)

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