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Similarly, it was recently reported that the expression of mitochondria-specific markers ( PGC1 , AMPK , SIRT1 , and cytochrome b , etc.) along with the protein levels of electron transport chain (complexes I, II, III, IV, and V) in osteocytes are not significant differences between bGH Tg and control mice (Liu et al., 2019)

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In the presence of FDX2 deficiency, mitochondrial iron overload occurs and p53 expression decreases, suggesting that FDX2 can transduce FDXR signals to regulate processes such as iron homeostasis, p53 expression, and tumor suppression (Zhang et al., 2017)