what's the difference between a semaglutide and tirzepatide caused roughly half as many patients to stop treatment because of gastrointestinal side effects as semaglutide. In first major head-to-head obesity trial, GI side effects caused treatment discontinuation in: Tirzepatide Tirzepatide Vs Semaglutide: Which One

This mechanism may be particularly relevant for patients who had significant insulin resistance before starting GLP-1 therapy

L.HubschA.ZhaoT.Aetesam-Ur-RahmanM.et al (2018)

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Sometimes, modestly, and only as one piece of a bigger plan

Take a look at the side effects listed above one more time before answering