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In the first reaction, NADPH is consumed by AR, which can result in OxS since NADPH is required for reducing GSSG to GSH (by GR) and GSH is required for the reducing peroxides by the GPX system (see Figure 2)

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If acid reflux is a concern, patients should work closely with their doctor to find the best way to balance the benefits of semaglutide with any potential side effects