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Jonathan struggled to build muscle for years, despite packing in protein and sticking to a rigorous fitness routine

Your unique response may depend on: Your genetics Underlying metabolic factors Concurrent medications Whether you have diabetes (people with type 2 diabetes often experience slightly less weight loss on semaglutide than those without) Your diet choices matter What you eat significantly affects how hungry you feel, even on semaglutide

What GLP-1 medications appear to do well is reduce the intensity and frequency of cravings

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Now, Winfrey follows a routine that includes having her last meal by 4pm, drinking 5 litres of water daily, and adhering to WeightWatchers principles