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The placebo capsules were prepared 3 weeks before the intervention, and packed in the same bottles that the L-carnitine supplements were repacked in

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The aromatic side chain of Y31 of IGF1 is sandwiched between P5 in the L1 domain and P256 in the CRD, and is further surrounded by several other conserved hydrophobic residues in the CRD, including F241, F251, and I255 (Fig

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This property makes IGF1-LR3 a much more potent molecule