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NMSC can also be developed due to Genetic mutation such as a mutation in certain gene families named CYP450, GST(Glutathione S-transferase), p53 [46]

Chronically sun-damaged melanomas express low levels of nuclear glutathione-S-transferase-pi: an epidemiological and clinicopathological study in Italy

doi: 10.1073/pnas.92.18.8115

This role of DPP-4 was first demonstrated in 1993 when human serum was incubated with GLP-1 in the absence or presence of the DPP-4 inhibitors lys-pyrrolidide or diprotin A, showing that the inactivation of GLP-1 was prevented by the DPP-4 inhibitors (19)

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Intestinal tissues of IBD patients show elevated Th17 cells and pro-inflammatory factors (IL-17A, IL-17F, IL-23), contributing to intestinal inflammation (180182)