However, it's important to note that individual results may vary, and benefits may take several weeks or months to become visible
Organ growth concerns (acromegaly-like effects) are theoretically possible with chronic supraphysiological IGF-1 exposure, though no human studies document this outcome at research doses below 100 mcg daily for fewer than 12 weeks
In more severe deficiency situations (more common in metabolic disorders), episodes of hypoglycaemia or cardiac abnormalities may appear
But by the third day, the magic happens Thin sheets of the epidermis skin will start to peel
Refyne is a bit softer, and so it creates a more natural result when placed superficially, as compared to Defyne
This work was supported by NIH grant R01DK031036 (to CRK) and Joslin Diabetes Research Center (DRC) grant (P30DK036836)