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What they found: Melanotan II is 100 to 1000 more potent than native -MSH in melanocyte assays Cyclization preserves the active conformation longer than linear -MSH Activates all four functional melanocortin receptors (MC1R, MC3R, MC4R, MC5R) In vivo: visible pigmentation of lizard skin within hours, not days as with -MSH Why it matters: This is the foundational publication of Melanotan II

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For patients with dark skin or for those who would like to address melasma, there are a number of non-invasive cosmetic treatment options that are more ideal than Fraxel

Subcutaneous injection bypasses the GI tract entirely, delivering KPV to the bloodstream for systemic distribution

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