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Moreover, fructose, once activated to fructose-1-phosphate, can also serve as a substrate for aldolase B and has been shown to increase NKCC2 functional expression in the kidney (Reungjui et al., 2007), is linked to NKCC2 function

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Metseras portfolio includes: injectable GLP-1 receptor agonist MET-097i (phase 2), amylin analog candidate MET-233i (phase I), two oral GLP-1 RA candidates expected to begin clinical trials imminently, and additional preclinical nutrient-stimulated hormone therapeutics

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GLP-1 stands for glucagon-like-peptide-1

Metformin, as an AMPK activator, inhibits the AMPK-mTOR-STAT3 axis, reduces mtDNA mutations and ROS generation in lupus models, and enhances mitophagy