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Corilagin alleviates ferroptosis in diabetic retinopathy by activating the Nrf2 signaling pathway

2016;18:23 LaRocca TJ, Stivison EA, Mal-Sarkar T, Hooven TA, Hod EA, Spitalnik SL, et al

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The researchers didnt feed glutathione to the yeast, but rather used evolutionary engineering to produce a specific strain that tends to produce more glutathione, as well as a glutathione-derived metal chelating compound called PC2 (phytochelatin 2)

Additionally, cocaine induces apoptosis in cerebral vascular smooth muscle cells, contributing to vasoconstriction and ischemia, resulting in significant neurological damage (Fonseca and Ferro, 2013)