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Chronic Gastrointestinal Inflammation Conditions such as inflammatory bowel disease and persistent intestinal irritation can create systemic inflammatory responses that affect metabolic health

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The logic here is that the underlying pathology is not resolving as cleanly as an acute mechanical injury, and ongoing mucosal protection may require sustained peptide signaling

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HSPA2 HSPA2, previously considered a relatively minor member of the HSP70 family, is now recognized as playing key roles in cell growth and mitosis within epithelial tissues, as well as participating in extracellular signaling (Sojka et al., 2023)