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In addition, daily oral simvastatin or lovastatin combined with PD-1 blockade in mice promoted tumor control and extended survival, notably, lovastatin plus anti-PD-1 treatment leads to rejection of oral cancer tumors of the head and neck cancer in 30% of mice

IPCS (1996) Environmental health criteria 180: Principles and methods for assessing direct immunotoxicity associated with exposure to chemicals

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PMID: 24522117 Mathew P, Wyllie R, Van Lente F, Steffen R.M, Kay M.H

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Similarly, for the RW subacute toxicity study, an increase in sodium and potassium levels were observed in the 1,000 mg/kg mice, which indicates possible kidney and/or heart dysfunction