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Acknowledgements This study was supported by the National Natural Science Foundation of China (81871790) & (81572167) and the Shanghai Hospital Development Center Foundation (SHDC12016110)

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Dihexa was administered to the APP/PS1 mice intraperitoneally from 6 to 9 months of age and 0.9% saline was administered to the wild type group once per day over a three month time period

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